MAPPING RAT-BRAIN STRUCTURES ACTIVATED DURING ETHANOL WITHDRAWAL - ROLE OF GLUTAMATE AND NMDA RECEPTORS

被引：69

作者：

MORGAN, PF ^{[1
]}

NADI, NS ^{[1
]}

KARANIAN, J ^{[1
]}

LINNOILA, M ^{[1
]}

机构：

[1] NINCDS,MED NEUROL BRANCH,BETHESDA,MD 20892

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION | 1992年 / 225卷 / 03期

关键词：

ETHANOL; C-FOS; GLUTAMATE; NMDA (N-METHYL-D-ASPARTATE); HYBRIDIZATION (INSITU);

D O I：

10.1016/0922-4106(92)90023-O

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Brain structures activated during ethanol withdrawal have been mapped by visualizing c-fos mRNA expression. The regional distribution of c-fos mRNA in brain during ethanol withdrawal can be mimicked by acute injection of N-methyl-D-aspartic acid (NMDA) and is stereospecifically blocked by the NMDA receptor antagonist, MK-801. The findings reveal that the dentate gyrus and piriform cortex are selectively activated during ethanol withdrawal and suggest that this may be mediated by glutamate activation of NMDA receptors.

引用

页码：217 / 223

页数：7

共 37 条

[1] INVOLVEMENT OF COMMON AND CELL TYPE-SPECIFIC PATHWAYS IN C-FOS GENE-CONTROL - STABLE INDUCTION BY CAMP IN MACROPHAGES [J].