ACID-BASE EQUILIBRIA IN SUBSTITUTED 4-QUINOLONE CARBOXYLIC-ACID SOLUTIONS

被引：28

作者：

JELIKIC, M

VESELINOVIC, D

DJURDJEVIC, P

机构：

[1] SVETOZAR MARKOVIC UNIV, FAC SCI, POB 60, YU-34000 KRAGUJEVAC, YUGOSLAVIA

[2] UNIV BELGRADE, FAC PHARM, YU-11000 BELGRADE, YUGOSLAVIA

[3] UNIV BELGRADE, FAC SCI, DEPT PHYS CHEM, YU-11000 BELGRADE, YUGOSLAVIA

来源：

TALANTA | 1992年 / 39卷 / 06期

关键词：

D O I：

10.1016/0039-9140(92)80078-R

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The protonation constants of some substituted 4-quinolone carboxylic acid anions (ofloxacin, pefloxacin and ciprofloxacin) were determined in lithium chloride solution of various concentrations at 293, 303 and 313 K using the pH-metric and spectrophotometric methods. The values of thermodynamic parameters (DELTA-G, DELTA-H and DELTA-S) for the first protonation step of these anions in 0.1M lithium chloride at 293 K, are reported. The formation of intramolecular hydrogen bonds is discussed.

引用

页码：665 / 670

页数：6

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[2]

Bell R. P., 1973, PROTON CHEM

[3]

BRYSKIER A, 1985, INT C CHEMOTHERAPY

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