CELL-ADHESION MOLECULE L1 GUIDES CELL-MIGRATION IN PRIMARY REAGGREGATION CULTURES OF MOUSE CEREBELLAR CELLS

被引：36

作者：

ASOU, H ^{[1
]}

MIURA, M ^{[1
]}

KOBAYASHI, M ^{[1
]}

UYEMURA, K ^{[1
]}

ITOH, K ^{[1
]}

机构：

[1] CHILDRENS HOSP RES FDN,CINCINNATI,OH 45229

来源：

NEUROSCIENCE LETTERS | 1992年 / 144卷 / 1-2期

关键词：

L1; MOLECULE; CELL MIGRATION; NEURON; CELL ADHESION MOLECULE; CULTURE; CEREBELLUM;

D O I：

10.1016/0304-3940(92)90754-U

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We demonstrate a new assay in vitro using reaggregated cerebellar neurons in order to test the role of the L1 molecule in migration events. Cells other than neurons were eliminated in these cultures. Cerebellar neuron reaggregates plated on L1 molecule substrates migrated at rates similar to those observed in vivo. This migration was blocked by anti-L1 antibody. These findings suggest that this culture could provide a useful system with which to directly study relationships between neuron migration and adhesion molecules.

引用

页码：221 / 224

页数：4

共 18 条

[1]

CHUNG CM, 1990, EXPERIENTIA, V46, P882

[2] CELL-ADHESION MOLECULES - IMPLICATIONS FOR A MOLECULAR HISTOLOGY [J].