LEPTOLSTATIN FROM STREPTOMYCES SP SAM1595, A NEW GAP PHASE-SPECIFIC INHIBITOR OF THE MAMMALIAN-CELL CYCLE .2. PHYSICOCHEMICAL PROPERTIES AND STRUCTURE

被引：14

作者：

ABE, K

YOSHIDA, M

NAOKI, H

HORINOUCHI, S

BEPPU, T

机构：

[1] UNIV TOKYO,FAC AGR,DEPT AGR CHEM,BUNKYO KU,TOKYO 113,JAPAN

[2] SUNBOR,OSAKA 618,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1993年 / 46卷 / 05期

关键词：

D O I：

10.7164/antibiotics.46.735

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Leptolstatin, a product from Streptomyces sp. SAM1595, is a gap phase-specific inhibitor of the mammalian cell cycle. Physico-chemical properties and spectrometric analyses showed that the structure of leptolstatin is (2Z,6E,8Z,12E,14E,22E)-19,24-dihydroxy-8,10,14,16,18,20,22-hepta-methyl-17-oxo-2,6,8,12,14,22-tetracosahexaen-5-olide.

引用

页码：735 / 740

页数：6

共 13 条

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