ANTIMALARIAL ACTIVITY OF SESQUITERPENES FROM THE MARINE SPONGE ACANTHELLA-KLETHRA

被引：77

作者：

ANGERHOFER, CK ^{[1
]}

PEZZUTO, JM ^{[1
]}

KONIG, GM ^{[1
]}

WRIGHT, AD ^{[1
]}

STICHER, O ^{[1
]}

机构：

[1] SWISS FED INST TECHNOL,DEPT PHARM,CH-8092 ZURICH,SWITZERLAND

来源：

JOURNAL OF NATURAL PRODUCTS | 1992年 / 55卷 / 12期

关键词：

D O I：

10.1021/np50090a014

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Five sesquiterpenoids containing isonitrile or isothiocyanate groups were isolated from the sponge Acanthella klethra. Compounds 1 and 2 were identified as axisonitrile 3 and the corresponding isothiocyanate derivative, respectively. Compounds 3-5 were found to be eudesmane sesquiterpenes. None of these compounds was cycotoxic toward cultured KB-3 cells, but varying degrees of activity were observed with cultured Plasmodium falciparum. Compound 1 demonstrated greatest promise as an antimalarial agent.

引用

页码：1787 / 1789

页数：3

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