ENZYMATIC-SYNTHESIS OF 4-METHYL-L-GLUTAMIC AND 4-ETHYL-L-GLUTAMIC ACIDS

被引：24

作者：

ECHALIER, F ^{[1
]}

CONSTANT, O ^{[1
]}

BOLTE, J ^{[1
]}

机构：

[1] UNIV CLERMONT FERRAND,CHIM ORGAN BIOL LAB,CNRS,URA 485,F-63177 CLERMONT FERRAND,FRANCE

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1993年 / 58卷 / 10期

关键词：

D O I：

10.1021/jo00062a015

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This paper reports the activity of glutamic oxalacetic aminotransferase (GOT) from pig heart and bacteria for racemic 4-hydroxy-, 4-methyl-, and 4-ethyl-2-ketoglutaric acids. These compounds are good substrates for GOT with V(max) values of, respectively, 70, 90, and 130% relative to the natural substrate, 2-ketoglutaric acid. GOT displays high enantioselectivity toward 4-methyl-2-ketoglutaric acid and 4-ethyl-2-ketoglutaric acid; the synthesis of both diastereoisomers of the corresponding 4-substituted L-glutamic acids is thus possible.

引用

页码：2747 / 2750

页数：4

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