SIMIAN VIRUS-40 LARGE T-ANTIGEN ASSOCIATES WITH CYCLIN-A AND P33(CDK2)

被引：39

作者：

ADAMCZEWSKI, JP ^{[1
]}

GANNON, JV ^{[1
]}

HUNT, T ^{[1
]}

机构：

[1] ICRF, CLARE HALL LABS, S MIMMS EN6 3LD, HERTS, ENGLAND

来源：

JOURNAL OF VIROLOGY | 1993年 / 67卷 / 11期

关键词：

D O I：

10.1128/JVI.67.11.6551-6557.1993

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In this paper we Provide evidence that a fraction of large T antigen of simian virus 40 (SV40) interacts with cyclin A and p33cdk2 in both virus-infected and stably transformed cells. Immunoprecipitates of SV40 large T antigen from SV40-infected or SV40 large-T-antigen-tranSformed cells contain cyclin A, p33cdk2, and histone H1 kinase activity. Conversely, immunoprecipitates Of cyclin A from these cells contain SV40 large T antigen. In this respect, SV40 large T antigen has properties similar to those of the E1A oncogene of adenoviruses and the E7 oncogene of human papillomaviruses.

引用

页码：6551 / 6557

页数：7

共 50 条

[1] CYCLIN-A AND THE RETINOBLASTOMA GENE-PRODUCT COMPLEX WITH A COMMON TRANSCRIPTION FACTOR
BANDARA, LR
ADAMCZEWSKI, JP
HUNT, T
LATHANGUE, NB
[J]. NATURE, 1991, 352 (6332) : 249 - 251
[2] BANDARA LR, 1992, J CELL SCI, P77
[3] IDENTIFICATION OF A REGION OF SIMIAN VIRUS-40 LARGE T-ANTIGEN REQUIRED FOR CELL-TRANSFORMATION
CHEN, S
PAUCHA, E
[J]. JOURNAL OF VIROLOGY, 1990, 64 (07) : 3350 - 3357
[4] CLEVELAND DW, 1977, J BIOL CHEM, V252, P1102
[5] CELLULAR PROTEINS REACTIVE WITH MONOCLONAL-ANTIBODIES DIRECTED AGAINST SIMIAN VIRUS-40 T-ANTIGEN
CRAWFORD, L
LEPPARD, K
LANE, D
HARLOW, E
[J]. JOURNAL OF VIROLOGY, 1982, 42 (02) : 612 - 620
[6] SV40 LARGE TUMOR-ANTIGEN FORMS A SPECIFIC COMPLEX WITH THE PRODUCT OF THE RETINOBLASTOMA SUSCEPTIBILITY GENE
DECAPRIO, JA
LUDLOW, JW
FIGGE, J
SHEW, JY
HUANG, CM
LEE, WH
MARSILIO, E
PAUCHA, E
LIVINGSTON, DM
[J]. CELL, 1988, 54 (02) : 275 - 283
[7] A CYCLIN-A-PROTEIN KINASE COMPLEX POSSESSES SEQUENCE-SPECIFIC DNA-BINDING ACTIVITY - P33CDK2 IS A COMPONENT OF THE E2F-CYCLIN-A COMPLEX
DEVOTO, SH
MUDRYJ, M
PINES, J
HUNTER, T
NEVINS, JR
[J]. CELL, 1992, 68 (01) : 167 - 176
[8] ASSOCIATION OF HUMAN CYCLIN-E WITH A PERIODIC G(1)-S PHASE PROTEIN-KINASE
DULIC, V
LEES, E
REED, SI
[J]. SCIENCE, 1992, 257 (5078) : 1958 - 1961
[9] CELL-CYCLE CONTROL OF DNA-REPLICATION BY A HOMOLOG FROM HUMAN-CELLS OF THE P34CDC2 PROTEIN-KINASE
DURSO, G
MARRACCINO, RL
MARSHAK, DR
ROBERTS, JM
[J]. SCIENCE, 1990, 250 (4982) : 786 - 791
[10] CDC2 FAMILY KINASES PHOSPHORYLATE A HUMAN CELL-DNA REPLICATION FACTOR, RPA, AND ACTIVATE DNA-REPLICATION
DUTTA, A
STILLMAN, B
[J]. EMBO JOURNAL, 1992, 11 (06) : 2189 - 2199

← 1 2 3 4 5 →