THE USE OF WELL-DEFINED BIOMARKERS (SUCH AS BLOOD LEAD) IN RISK ASSESSMENT

被引:3
作者
HATTIS, D
机构
[1] Center for Technology, Environment, and Development (CENTED), George Perkins Marsh Institute, Clark University, Worcester, 01610, MA
关键词
D O I
10.1007/BF01747918
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Biomarkers have a number of different uses in risk assessment, including (1) a variety of applications as dosimeters, (2) as an aid in quantifying inter-individual variability in susceptibility; and (3) as intermediate effect parameters that can help the analyst predict outcomes that are difficult to measure directly. This paper focuses primarily on applications of the first and second types, which are most frequently found in assessing risks from inorganic compounds.
引用
收藏
页码:223 / 228
页数:6
相关论文
共 14 条
[1]  
Ballew M., Hattis D., Reproductive Effects of Glycol Ethers in Females--A Quantitative Analysis., (1989)
[2]  
Cunnane C., Unbiased plotting positions-a review, J. Hydrol., 37, pp. 205-222, (1978)
[3]  
Hattis D., The use of biological markers in risk assessment, Statistical Science, 3, pp. 358-366, (1988)
[4]  
Hattis D., Abdollahzadeh S., Franklin C.A., Strategies for testing the ‘irritation-signaling’ model for chronic lung effects of fine acid particles, JAPCA, 40, pp. 322-330, (1990)
[5]  
Hattis D., Erdreich L., Ballew M., Human variability in susceptibility to toxic chemicals — A preliminary analysis of pharmacokinetic data from normal volunteers, Risk Analysis, 7, pp. 415-426, (1987)
[6]  
Haitis D., Shapiro K., Analysis of dose/time/response relationships for chronic toxic effects — The case of acrylamide, NeuroToxicology, 11, pp. 219-236, (1990)
[7]  
Haitis D., Silver K., Use of mechanistic data in occupational health risk assessment--The example of diesel particulates, Occupational Health Risk Assessment: Directions for the '90's, (1993)
[8]  
Hattis D., Smith J., What's wrong with quantitative risk assessment, Quantitative Risk Assessment, Biomedical Ethics Reviews: 1986, pp. 57-105, (1987)
[9]  
Hattis D., Welch L.S., Schrader S.M., Male Fertility Effects of Glycol Ethers--A Quantitative Analysis, (1988)
[10]  
Seafood Safety, (1991)