SYNTHESIS AND BIOLOGICAL PROPERTIES OF 9-DEOXO-16, 16-DIMETHYL-9-METHYLENE-PGE2

被引：18

作者：

KIMBALL, FA

BUNDY, GL

ROBERT, A

WEEKS, JR

机构：

[1] Research Laboratories The Upjohn Company, Kalamazoo

来源：

PROSTAGLANDINS | 1979年 / 17卷 / 05期

关键词：

D O I：

10.1016/S0090-6980(79)80038-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The in vivo monkey uterine stimulating potency of 9-deoxo-16,16-dimethyl-9-methylene-PGE2 is similar to that of 16,16-dimethyl-PGE2 and approximately 15 times that of PGE2. Low doses of this compound stimulated uterine contractions when administered vaginally. Pregnancy was terminated prematurely following subcutaneous, intramuscular or vaginal suppository treatment. Estimates of potential for gastrointestinal side effects using the rat enteropooling assay and in vivo monkey effects indicate that diarrhea will be substantially reduced with retention of uterine stimulating potency. © 1979.

引用

页码：657 / 666

页数：10

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