EFFECTS OF MAMMALIAN CORTICOTROPIN AND PROGESTERONE ON CORTICOID PRODUCTION BY CHICKEN ADRENAL TISSUE IN-VITRO

Mammalian ACTH and/or progesterone increased both corticosterone and aldosterone production by chicken adrenal tissue in vitro. Corticosterone secretion under the several treatments was of the following order: control < ACTH < progesterone < ACTH and progesterone; aldosterone secretion was of the following order: control < progesterone < ACTH ≤ ACTH and progesterone. The data indicate that the ability of ACTH to increase aldosterone secretion is not an artifact of the in vitro method of investigation reflecting an increased pool of corticosterone in the medium and its conversion to aldosterone, but instead represents, at least in part, a direct action of ACTH on aldosterone secretion. © 1970.