ACTION OF D-PROPRANOLOL IN MANIC PSYCHOSES

被引：13

作者：

MOLLER, HJ ^{[1
]}

VONZERSSEN, D ^{[1
]}

EMRICH, HM ^{[1
]}

KISSLING, W ^{[1
]}

CORDING, C ^{[1
]}

SCHIETSCH, HJ ^{[1
]}

RIEDEL, E ^{[1
]}

机构：

[1] FREE UNIV BERLIN, INST BIOCHEM, D-1000 BERLIN 19, FED REP GER

来源：

ARCHIV FUR PSYCHIATRIE UND NERVENKRANKHEITEN | 1979年 / 227卷 / 04期

关键词：

Beta blockers; Manic psychoses;

D O I：

10.1007/BF00344815

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Six manic patients were treated with high doses of d-propranolol or d- and dl-propranolol in a double-blind, placebo controlled study. The following variables were measured: propranolol dosage, propranolol serum concentration, pulse frequency, blood pressure, and psychotic behavior. In all cases an improvement was noticed. High dosages were necessary to obtain sufficient effect. The antimanic property of d-propranolol was approximately 50% smaller than the antimanic property of dl-propranolol. We conclude that at least some part of the antimanic action of beta-blockers is independent from the beta-blocking property. © 1979 Springer-Verlag.

引用

页码：301 / 317

页数：17

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