ANTICELLULAR EFFECTS OF 9-(2-HYDROXYETHOXYMETHYL) GUANINE AGAINST HERPES-SIMPLEX VIRUS-TRANSFORMED CELLS

被引：52

作者：

NISHIYAMA, Y ^{[1
]}

RAPP, F ^{[1
]}

机构：

[1] PENN STATE UNIV, MILTON S HERSHEY MED CTR, COLL MED, SPECIALIZED CANC RES CTR, HERSHEY, PA 17033 USA

来源：

JOURNAL OF GENERAL VIROLOGY | 1979年 / 45卷 / OCT期

关键词：

D O I：

10.1099/0022-1317-45-1-227

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The guanine derivative 9-(2-hydroxyethoxymethyl) guanine (acycloguanosine), a potent inhibitor of herpes simplex virus (HSV) multiplication, was found to have marked anticellular activity against HSV-transformed thymidine kinase-positive cells. HSV type I-transformed cells were more sensitive to the drug than HSV type 2-transformed cells.

引用

页码：227 / 230

页数：4

共 8 条

[1] HERPES-SIMPLEX VIRUS AS A SOURCE F THYMIDINE KINASE FOR THYMIDINE KINASE-DEFICENT MOUSE CELLS - SUPPRESSION AND REACTIVATION OF VIRAL ENZYME
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[3] FURMAN PA, 1978, 18TH INT C ANT AG CH
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[7] 9-(2-HYDROXYETHOXYMETHYL)GUANINE ACTIVITY AGAINST VIRUSES OF HERPES GROUP
SCHAEFFER, HJ
BEAUCHAMP, L
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ELION, GB
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[J]. NATURE, 1978, 272 (5654) : 583 - 585
[8] QUANTIFICATION OF HERPES-SIMPLEX VIRUS-DNA PRESENT IN BIOCHEMICALLY TRANSFORMED MOUSE CELLS AND THEIR REVERTANTS
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