DAILY PROFILES OF SALIVARY CORTISOL IN HYDROCORTISONE TREATED CHILDREN WITH CONGENITAL ADRENAL-HYPERPLASIA

被引：13

作者：

HAMPL, R ^{[1
]}

FORETOVA, L ^{[1
]}

SULCOVA, J ^{[1
]}

STARKA, L ^{[1
]}

机构：

[1] RES INST PAEDIAT, BRNO, CZECHOSLOVAKIA

来源：

EUROPEAN JOURNAL OF PEDIATRICS | 1990年 / 149卷 / 04期

关键词：

Congenital adrenal hyperplasia; Salivary cortisol;

D O I：

10.1007/BF02106278

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Daily profiles of salivary cortisol were determined in 14 cortisol-treated children with congenital adrenal hyper-plasia (CAH) due to 21-hydroxylase deficiency, and in 5 healthy sibs. The results showed considerable individual variation irrespective of the dose of hormone, reflecting the different rates of cortisol metabolism and transport. Maximum salivary cortisol levels were reached 1-2 h following oral administration of hydrocortisone. The determination of salivary cortisol may be useful for optimal dosage timing, i.e. to imitate the daily rhythm of normal cortisol secretion. © 1990 Springer-Verlag.

引用

页码：232 / 234

页数：3

共 11 条

[1] SIMULTANEOUS RADIOIMMUNOASSAY OF ANDROSTENEDIONE, DEHYDROEPIANDROSTERONE AND 11-BETA-HYDROXYANDROSTENEDIONE IN PLASMA [J].