REGIONAL DISTRIBUTION OF NEUROPEPTIDE-GAMMA AND OTHER TACHYKININ PEPTIDES DERIVED FROM THE SUBSTANCE-P GENE IN THE RAT

被引：77

作者：

TAKEDA, Y ^{[1
]}

TAKEDA, J ^{[1
]}

SMART, BM ^{[1
]}

KRAUSE, JE ^{[1
]}

机构：

[1] WASHINGTON UNIV,SCH MED,DEPT ANAT & NEUROBIOL,ST LOUIS,MO 63110

来源：

REGULATORY PEPTIDES | 1990年 / 28卷 / 03期

关键词：

Gastrointestinal tract; Neurokinin A; Neuropeptide K; Salivary gland; Substance P;

D O I：

10.1016/0167-0115(90)90030-Z

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Substance P (SP) and multiple neurokinin A (NKA)-related peptides can be derived from α-, β- and/or γ-preprotachykinin (PPT) mRNAs. In this study, the relative concentrations of the tachykinin peptides derived from the SP gene in rat brain, duodenum, jejunum, submandibular gland, parotid gland, urinary bladder and vas deferens was determined using high-performance liquid chromatography (HPLC) and radioimmunoassays (RIAs). In all tissues, SP levels were the highest. The relative abundance of NKA-related peptides was NKA >; neuropeptide γ (NPγ) = neuropeptide K (NPK) >; NKA(3-10). These results demonstrate that multiple tachykinin peptides are present in tissues where the SP gene is expressed, and that the NKA portion of the β- and γ-PPT precursors can be differentially processed posttranslationally in rat tissues into NKA, NPK, NPγ and/or NKA (3-10). © 1990.

引用

页码：323 / 333

页数：11

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