TRI-NORMAL-BUTYLTIN(IV) DERIVATIVES OF L-CYSTEINE ETHYL-ESTER, N-ACETYL-L CYSTEINE AND ALPHA-GLUTAMYL CYSTEINYL GLYCINE (GLUTATHIONE REDUCED)

Syntheses and spectroscopic data (1H and 13C N.M.R., I.R. and Mössbauer) are presented for L-cysteine ethyl ester, N-acetyl L-cysteine and Glutathione (reduced) tri-n-butyl tin derivatives. The L-cysteine ethyl ester compound appears to be four coordinate with a SnS bond while the N-acetyl L-cysteine complex contains a four coordinate (n-C4H9)3Sn-S moiety and a (n-C4H9)3SnOCO grouping containing chelating carboxylate. In moderately concentrated solutions, dimeric species exist with hyrogen bonding between NH and CO groups. The Glutathione complex is strongly associated, probably via N→Sn coordination. The (n-C4H9)3Sn entities in this complex are bonded to the cysteine and glycine residues. © 1979.