RELATION BETWEEN POLYPORPHYRIN DISTRIBUTION AND BLOOD-BRAIN-BARRIER CHANGES IN THE RAT GLIOMA MODEL

被引：16

作者：

JI, Y ^{[1
]}

WALSTAD, DL ^{[1
]}

BROWN, JT ^{[1
]}

POWERS, SK ^{[1
]}

机构：

[1] UNIV N CAROLINA,DIV NEUROL SURG,CB 7060,148 BURNETT WOMACK,CHAPEL HILL,NC 27599

来源：

LASERS IN SURGERY AND MEDICINE | 1992年 / 12卷 / 02期

关键词：

BRAIN TUMOR; HEMATOPORPHYRIN DERIVATIVE; PHOTODYNAMIC THERAPY; RAT GLIOMA;

D O I：

10.1002/lsm.1900120210

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Photofrin(TM) (a polyporphyrin mixture) distribution in a rat glioma model was studied in relation to changes in the blood brain barrier (BBB). At selected intervals after intraperitoneal injection of Photofrin(TM), the concentration of polyporphyrins (PP) and Evans Blue Dye, an indicator of BBB permeability, were determined for tumor, brain adjacent to tumor (BAT), and normal brain tissue. Contrary to earlier reports of maximal accumulation at 4-24 hours, tumor levels of PP increased throughout the 96 hour measurement period. During the early stages of tumor development, PP uptake by tumor appeared to be less correlated to BBB disruption. We conclude that passive diffusion through an incompetent BBB does not completely explain PP accumulation in tumor tissue.

引用

页码：174 / 179

页数：6

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