CARDIAC ATRIAL-NATRIURETIC-FACTOR DURING EVOLUTION OF CONGESTIVE-HEART-FAILURE

被引:51
作者
PERRELLA, MA [1 ]
SCHWAB, TR [1 ]
OMURCHU, B [1 ]
REDFIELD, MM [1 ]
WEI, CM [1 ]
EDWARDS, BS [1 ]
BURNETT, JC [1 ]
机构
[1] MAYO CLIN & MAYO FDN, DEPT THORAC DIS, ROCHESTER, MN 55905 USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY | 1992年 / 262卷 / 04期
关键词
MYOCARDIUM; ATRIAL PEPTIDES; PROTEIN SYNTHESIS;
D O I
10.1152/ajpheart.1992.262.4.H1248
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Congestive heart failure (CHF) is a pathophysiological condition associated with increased plasma levels of atrial natriuretic factor (ANF), a peptide hormone of cardiac origin that participates in the homeostatic control of intravascular volume and vascular tone. Atrial myocytes serve as the principal source of ANF under physiological conditions, although recent studies have demonstrated that ventricular myocardium may also synthesize ANF in models of CHF associated with ventricular hypertrophy. The current study was designed to investigate the roles of atrial and ventricular myocardium to synthesize, store, and release ANF during the evolution of tachycardia-induced CHF in the dog. The present study demonstrates a persistent elevation of plasma ANF during the evolution of CHF. In acute CHF (3 h), plasma ANF increased independent of cardiac ANF synthesis. In chronic CHF (15 and 30 days), plasma ANF is maintained by an increase in atrial synthesis and release of the peptide, without recruitment of ventricular ANF synthesis. The present study demonstrates that in acute CHF the increase in plasma ANF is regulated by release of stored peptide, and in chronic CHF the persistent elevation of plasma ANF is maintained by an increase in atrial synthesis of ANF.
引用
收藏
页码:H1248 / H1255
页数:8
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