A NEW SUBFAMILY OF BACTERIAL ABC-TYPE TRANSPORT-SYSTEMS CATALYZING EXPORT OF DRUGS AND CARBOHYDRATES

被引：96

作者：

REIZER, J ^{[1
]}

REIZER, A ^{[1
]}

SAIER, MH ^{[1
]}

机构：

[1] UNIV CALIF SAN DIEGO,DEPT BIOL,0116,LA JOLLA,CA 92093

来源：

PROTEIN SCIENCE | 1992年 / 1卷 / 10期

关键词：

ABC-TYPE PERMEASES; ATP HYDROLYSIS; DRUG RESISTANCE; EVOLUTION; NODULATION; OLIGOMERIC CHANNELS; PHYLOGENETIC TREE; POLYSACCHARIDE EXPORT; SOLUTE TRANSPORT;

D O I：

10.1002/pro.5560011012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Sequence comparison studies revealed that the drug resistance transporter of Streptomyces peucetius (DrrAB) and two nodulation gene products (NodIJ) of Rhizobium leguminosarum are homologous to proteins encoded by three sets of genes that comprise capsular polysaccharide export systems in gram-negative bacteria: KpsTM of Escherichia coli, BexABC of Haemophilus influenzae, and CtrDCB of Neisseria meningitidis. These five systems comprise a new subfamily within the family of ATP binding cassette (ABC)-type transporters. We have termed this subfamily the ABC-2 subfamily. For three of the systems comprising this subfamily (Drr, Nod, and Kps) only one integral membrane constituent has been identified, whereas for the other two systems (Bex and Ctr) two dissimilar integral membrane constituents have been found. This observation suggests that the transmembrane channels of ABC-2-type transporters can be formed of homo- or heterooligomers as is true of several other classes of transport systems.

引用

页码：1326 / 1332

页数：7

共 23 条

[1] INTERNAL DUPLICATION AND HOMOLOGY WITH BACTERIAL TRANSPORT PROTEINS IN THE MDR1 (P-GLYCOPROTEIN) GENE FROM MULTIDRUG-RESISTANT HUMAN-CELLS [J].