NOVEL ACETOGENINS FROM THE LEAVES OF ANNONA-PURPUREA

被引:30
作者
CEPLEANU, F
OHTANI, K
HAMBURGER, M
GUPTA, MP
SOLIS, P
HOSTETTMANN, K
机构
[1] UNIV LAUSANNE,BEP,ECOLE PHARM,INST PHARMACOGNOSIE & PHYTOCHIM,CH-1015 LAUSANNE,SWITZERLAND
[2] UNIV PANAMA,SCH PHARM,PHARMACOGNOST STUDY PANAMANIAN FLORA RES CTR,PANAMA CITY,PANAMA
关键词
D O I
10.1002/hlca.19930760324
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The CH2Cl2 extract of the leaves of Annona purpurea L. (Annonaceae) showed strong brine shrimp toxicity and pronounced activity against larvae of the yellow-fever mosquito Aedes aegypti. Activity-directed fractionation of the extract by a combination of column chromatography on silica gel, gel filtration, and high-pressure liquid chromatography led to the isolation of acetogenins 1-6 as the main active principles. The structures of two novel acetogenins named purpureacin 1 (5) and purpureacin 2 (6) were elucidated by spectroscopic analysis (UV, EI- and DCI-MS, EI-MS of Me3Si derivatives, H-1- and C-13-NMR). The configuration of 5 and 6 was not established due to the limited sample amount. Compounds 3-6 also showed antifungal activity against Candida albicans, and 5 was slightly active against Bacillus subtilis.
引用
收藏
页码:1379 / 1388
页数:10
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