SENILE DEMENTIA OF THE LEWY BODY TYPE HAS AN APOLIPOPROTEIN-E EPSILON-4 ALLELE FREQUENCY INTERMEDIATE BETWEEN CONTROLS AND ALZHEIMERS-DISEASE

被引：55

作者：

HARDY, J

CROOK, R

PRIHAR, G

ROBERTS, G

RAGHAVAN, R

PERRY, R

机构：

[1] UNIV S FLORIDA,DEPT PHARMACOL,SUNCOAST ALZHEIMERS DIS LABS,TAMPA,FL 33613

[2] UNIV S FLORIDA,DEPT NEUROL,SUNCOAST ALZHEIMERS DIS LABS,TAMPA,FL 33613

[3] UNIV S FLORIDA,DEPT BIOCHEM,SUNCOAST ALZHEIMERS DIS LABS,TAMPA,FL 33613

[4] SMITHKLINE BEECHAM PHARMACEUT,HARLOW CM19 5AD,ESSEX,ENGLAND

[5] NEWCASTLE GEN HOSP,DEPT NEUROPATHOL,NEWCASTLE TYNE NE4 6BE,TYNE & WEAR,ENGLAND

来源：

NEUROSCIENCE LETTERS | 1994年 / 182卷 / 01期

关键词：

ALZHEIMERS DISEASE; PARKINSONS DISEASE; LEWY BODY; GENETICS; APOLIPOPROTEIN E;

D O I：

10.1016/0304-3940(94)90190-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have examined the apolipoprotein E (ApoE) allele distributions in Alzheimer's disease, Parkinson's disease, senile dementia of the Lewy body type and neurologically normal controls. We have confirmed the strong genetic association between the epsilon 4 allele and Alzheimer's disease, shows that there is no association between the epsilon 4 allele and Parkinson's disease and shown that senile dementia of the Lewy body type has an epsilon 4 allele distribution intermediate between Alzheimer's disease and Parkinson's disease. On this basis, we suggest that senile dementia of the Lewy body type represents the co-occurrence of two syndromes.

引用

页码：1 / 2

页数：2

共 11 条

[1] GENE DOSE OF APOLIPOPROTEIN-E TYPE-4 ALLELE AND THE RISK OF ALZHEIMERS-DISEASE IN LATE-ONSET FAMILIES [J].