REGULATION OF B-CELL ACTIVATION BY CD45 - A QUESTION OF MECHANISM

被引：44

作者：

JUSTEMENT, LB

BROWN, VK

LIN, JJ

机构：

[1] Louis B. Justement, Vergil K. Brown and Jiejian Lin are, the Dept of Microbiology and Immunology, Galveston, TX 77555-1019, J-19, Medical Research Building

来源：

IMMUNOLOGY TODAY | 1994年 / 15卷 / 09期

关键词：

D O I：

10.1016/0167-5699(94)90268-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent studies have demonstrated that the protein tyrosine phosphatase CD45 plays an integral role in regulation of B-cell function. Most notably, expression of this phosphatase is required for activation of B lymphocytes and entry into the cell cycle. Here, Louis Justement and colleagues review current information concerning the function of CD45 in the B cell. The discussion focuses on two questions that are of central importance: what are the physiological substrates for CD45 and how does reversible tyrosine phosphorylation affect their function?

引用

页码：399 / 406

页数：8

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