TETRAZOLES OF MANNO-PYRANOSES AND RHAMNO-PYRANOSES - INHIBITION OF GLYCOSIDASES BY TETRAZOLES AND OTHER MANNOSE MIMICS

被引：34

作者：

BRANDSTETTER, TW

DAVIS, B

HYETT, D

SMITH, C

HACKETT, L

WINCHESTER, BG

FLEET, GWJ

机构：

[1] OXFORD CTR MOLEC SCI,DYSON PERRINS LAB,OXFORD OX1 3QY,ENGLAND

[2] GLAXO WELLCOME MED RES CTR,STEVENAGE SG1 2NY,HERTS,ENGLAND

[3] UNIV LONDON,INST CHILD HLTH,LONDON WC1 1EH,ENGLAND

[4] UNIV LONDON,GREAT ORMOND ST HOSP CHILDREN,NHS TRUST,LONDON WC1 1EH,ENGLAND

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 41期

关键词：

D O I：

10.1016/0040-4039(95)01519-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of tetrazoles derived from D-mannopyranose and D-rhamnopyranose from L-gulonolactone is described. These and other materials are assessed as inhibitors of human liver glycosidases and delineate some structural features required for alpha- and beta-mannosidase and alpha-fucosidase inhibition.

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收藏

页码：7511 / 7514

页数：4

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