BIODISTRIBUTION AND RADIOIMMUNOPHARMACOKINETICS OF I-131 AMA MONOCLONAL-ANTIBODY IN ATHEROSCLEROTIC RABBITS

被引：20

作者：

CHAKRABARTI, M

CHENG, KT

SPICER, KM

KIRSCH, WM

FOWLER, SD

KELLN, W

GRIENDE, S

NEHLSENCANNARELLA, S

WILLERSON, R

SPICER, SS

KOCH, T

机构：

[1] MED UNIV S CAROLINA,RADIOL PHARM & NUCL MED DEPT HOSP PHARM,CHARLESTON,SC 29425

[2] MED UNIV S CAROLINA,RADIOL PHARM & NUCL MED DEPT RADIOL,CHARLESTON,SC 29425

[3] LOMA LINDA UNIV,MED CTR,LOMA LINDA,CA 92350

[4] UNIV S CAROLINA,SCH MED,DEPT PATHOL,COLUMBIA,SC 29208

[5] UNIV COLORADO,DEPT CHEM,BOULDER,CO 80309

来源：

NUCLEAR MEDICINE AND BIOLOGY | 1995年 / 22卷 / 06期

关键词：

D O I：

10.1016/0969-8051(95)00008-L

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 [临床医学]; 100207 [影像医学与核医学]; 1009 [特种医学];

摘要：

Monoclonal antibodies have been raised against Ama isolated from human and experimental atherosclerotic plaque. I-131-Ama-MoAb in the whole antibody form was injected into normal NZW rabbits and Watanabe hyperlipidemic rabbits. Biodistribution studies showed that atheromatous aortas hud a significantly higher (5-7X) uptake of I-131-Ama-MoAb than that of normal aortas. However. I-131-Ama-MoAb was cleared very slowly from atherosclerotic rabbits. As a result, atheromas could not be identified by imaging because of the low target to non-target ratios.

引用

页码：693 / 697

页数：5

共 12 条

[1]

APPLICATION OF NILE RED, A FLUORESCENT HYDROPHOBIC PROBE, FOR THE DETECTION OF NEUTRAL LIPID DEPOSITS IN TISSUE-SECTIONS - COMPARISON WITH OIL RED O [J].

FOWLER, SD ;

GREENSPAN, P .

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1985, 33 (08) :833-836

[2]

FOWLER SD, 1991, FASEB J*, V533, P942

[3]

FRAKER PJ, 1978, BIOCHEM BIOPH RES CO, V80, P849, DOI 10.1016/0006-291X(78)91322-0

[4]

HAISMA HJ, 1981, J NUCL MED, V37, P1890

[5]

KEIJIRO S, 1989, ATHEROSCLEROSIS, V79, P225

[6]

Khaw B A, 1992, J Nucl Biol Med, V36, P35

[7]

KHW BA, 1989, J NUCL MED, V30, P859

[8]

KIRSCH WM, 1991, FASEB J*, V533, P943

[9]

SYNTHESIS AND CHARACTERIZATION OF THE "3,5,5-TRIMETHYL-2-OXOPIPERAZIN-3-YL RADICAL - AN AMINO CARBOXAMIDO TYPE MEROSTABILIZED FREE-RADICAL [J].

KLEYER, DL ;

HALTIWANGER, RC ;

KOCH, TH .

JOURNAL OF ORGANIC CHEMISTRY, 1983, 48 (02) :147-152

[10]

KOCH TH, 1991, FASEB J, V533, P944

← 1 2 →