OXIDANTS SPONTANEOUSLY RELEASED BY ALVEOLAR MACROPHAGES OF CIGARETTE SMOKERS CAN INACTIVATE THE ACTIVE-SITE OF ALPHA1-ANTITRYPSIN, RENDERING IT INEFFECTIVE AS AN INHIBITOR OF NEUTROPHIL ELASTASE

被引:132
作者
HUBBARD, RC [1 ]
OGUSHI, F [1 ]
FELLS, GA [1 ]
CANTIN, AM [1 ]
JALLAT, S [1 ]
COURTNEY, M [1 ]
CRYSTAL, RG [1 ]
机构
[1] TRANSGENE SA, F-67000 STRASBOURG, FRANCE
关键词
D O I
10.1172/JCI113204
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
引用
收藏
页码:1289 / 1295
页数:7
相关论文
共 55 条
[1]  
ABBOUD RT, 1985, AM REV RESPIR DIS, V131, P79
[2]  
BEATTY K, 1980, J BIOL CHEM, V255, P3931
[3]  
Bieth J, 1986, REGULATION MATRIX AC, P217
[4]   INVIVO SIGNIFICANCE OF KINETIC CONSTANTS OF PROTEIN PROTEINASE-INHIBITORS [J].
BIETH, JG .
BIOCHEMICAL MEDICINE, 1984, 32 (03) :387-397
[5]   ALVEOLAR MACROPHAGE REPLICATION - ONE MECHANISM FOR THE EXPANSION OF THE MONONUCLEAR PHAGOCYTE POPULATION IN THE CHRONICALLY INFLAMED LUNG [J].
BITTERMAN, PB ;
SALTZMAN, LE ;
ADELBERG, S ;
FERRANS, VJ ;
CRYSTAL, RG .
JOURNAL OF CLINICAL INVESTIGATION, 1984, 74 (02) :460-469
[6]   ORIGIN, KINETICS, AND CHARACTERISTICS OF PULMONARY MACROPHAGES IN THE NORMAL STEADY-STATE [J].
BLUSSEVANOUDALBLAS, A ;
VANFURTH, R .
JOURNAL OF EXPERIMENTAL MEDICINE, 1979, 149 (06) :1504-1518
[7]   THE FUNCTIONAL-ACTIVITY OF ALPHA-1-PROTEINASE INHIBITOR IN BRONCHOALVEOLAR LAVAGE FLUIDS FROM HEALTHY-HUMAN SMOKERS AND NON-SMOKERS [J].
BOUDIER, C ;
PELLETIER, A ;
PAULI, G ;
BIETH, JG .
CLINICA CHIMICA ACTA, 1983, 132 (03) :309-315
[8]  
CAMPBELL EJ, 1983, J LAB CLIN MED, V101, P527
[9]   POTENTIAL MECHANISM OF EMPHYSEMA - ALPHA-1-PROTEINASE INHIBITOR RECOVERED FROM LUNGS OF CIGARETTE SMOKERS CONTAINS OXIDIZED METHIONINE AND HAS DECREASED ELASTASE INHIBITORY CAPACITY [J].
CARP, H ;
MILLER, F ;
HOIDAL, JR ;
JANOFF, A .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1982, 79 (06) :2041-2045
[10]  
CARP H, 1978, AM REV RESPIR DIS, V118, P617