SILICONE LUBRICANT FLUSHED FROM DISPOSABLE SYRINGES - DETERMINATION BY ATOMIC ABSORPTION SPECTROPHOTOMETRY

被引：22

作者：

MILLER, JR

HELPRIN, JJ

FINLAYSON, JS

机构：

[1] Division of Biologics Standards, National Institutes of Health, Bethesda, Maryland

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1969年 / 58卷 / 04期

关键词：

Atomic absorption spectroscopy—analysis; Methyl isobutyl ketone—silicone extraction; Plastic syringes—water removable silicone; Silicone lubricant; plastic syringes—analysis;

D O I：

10.1002/jps.2600580413

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Amounts of silicone removable from disposable plastic syringes were determined (as silicon) by the use of atomic absorption spectrophotometry. This method revealed that the silicone fluid employed as a lubricant was present in distilled water expressed from 20 to 60 percent of the syringes. As contrasted with the total silicone extractable by dissolving with methyl isobutyl ketone, water‐removable silicone appeared to be removed by a mechanical flushing action. Copyright © 1969 Wiley‐Liss, Inc., A Wiley Company

引用

页码：455 / +

页数：1