LANTADENE A TOXICITY IN SHEEP - MODEL FOR CHOLESTASIS

被引：27

作者：

PASS, MA ^{[1
]}

SEAWRIGHT, AA ^{[1
]}

LAMBERTON, JA ^{[1
]}

HEATH, TJ ^{[1
]}

机构：

[1] CSIRO, DIV APPL ORGAN CHEM, FISHERMANS BEND, VICTORIA, AUSTRALIA

来源：

PATHOLOGY | 1979年 / 11卷 / 01期

关键词：

D O I：

10.3109/00313027909063543

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Liver injury occurred after sheep were injected intravenously with the triterpene acid lantadene A, the toxic principle of the tropical plant Lantana camara. A single dose of 1-3 mg/kg of the compound caused mild hepatocellular injury characterized by transient rises in serum enzymes, with or without hyperbilirubinaemia. Higher doses resulted in hepatic necrosis. When low doses of the triterpene were given repeatedly over several days a cholestatic syndrome developed which appeared identical with that caused by consumption of the plant. This is a disease model which may be of value in experimental studies of intrahepatic cholestasis. This study provides evidence that lantadene A is hepatotoxic and does not require metabolism in the alimentary tract for toxicity in sheep. © 1979 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.

引用

页码：89 / 94

页数：6

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