LIPOSOME-ENTRAPPED CALCITONIN AND PARATHYROID-HORMONE ARE ORALLY EFFECTIVE IN RATS

被引：43

作者：

FUKUNAGA, M

MILLER, MM

DEFTOS, LJ

机构：

[1] VET ADM MED CTR, MAIL CODE V-111C, SAN DIEGO, CA 92161 USA

[2] UNIV CALIF SAN DIEGO, DEPT MED, LA JOLLA, CA 92093 USA

[3] KAWASAKI MED SCH, KURASHIKI, OKAYAMA 70101, JAPAN

来源：

HORMONE AND METABOLIC RESEARCH | 1991年 / 23卷 / 04期

关键词：

CALCITONIN; PARATHYROID HORMONE; LIPOSOMES; ORAL ADMINISTRATION;

D O I：

10.1055/s-2007-1003642

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We have demonstrated that liposomally entrapped calcitonin (CT) and parathyroid hormone (PTH) can be orally effective in regulating blood calcium. Liposomal CT produced hypocalcemia and liposomal PTH produced hypercalcemia upon oral administration to rats. Specific liposomal formulations were necessary to affect the appropriate decrease and increase in blood calcium concentration. Future extension of these studies may lead to clinically valuable forms of liposomal-peptide preparations.

引用

页码：166 / 167

页数：2

共 8 条

[1] LIPOSOME TECHNIQUES IN CELL BIOLOGY [J].