ANTIIDIOTYPIC ANTIBODIES IN PATIENTS WITH MONOCLONAL GAMMOPATHIES - RELATION TO THE TUMOR LOAD

被引：31

作者：

BERGENBRANT, S

OSTERBORG, A

HOLM, G

MELLSTEDT, H

LEFVERT, AK

机构：

[1] KAROLINSKA HOSP,IMMUNOL SERV,DEPT MED,S-10401 STOCKHOLM 60,SWEDEN

[2] KAROLINSKA HOSP,DEPT ONCOL RADIUMHEMMET,S-10401 STOCKHOLM 60,SWEDEN

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1991年 / 78卷 / 01期

关键词：

D O I：

10.1111/j.1365-2141.1991.tb04384.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The production of anti-idiotypic antibodies from Epstein-Barr virus transformed peripheral blood lymphocytes was analysed in 12 patients with multiple myeloma and monoclonal gammopathy of undetermined significance. A low anti-idiotype production was found in patients with advanced disease (multiple myeloma stage III), whereas the production was high in patients with multiple myeloma stage I and monoclonal gammopathy of undetermined significance (MGUS) (P < 0.01). The study supports the existence of an immunological network response in patients with monoclonal gammopathies.

引用

页码：66 / 70

页数：5

共 30 条

[1] ANTIGEN AND LYMPHOCYTE-T MEDIATED SUPPRESSION OF MYELOMA CELLS - MODEL SYSTEMS FOR REGULATION OF LYMPHOCYTE FUNCTION [J].