DISTANT METASTASES IN DIFFERENTIATED THYROID-CANCER - LONG-TERM RESULTS OF RADIOIODINE TREATMENT AND STATISTICAL-ANALYSIS OF PROGNOSTIC FACTORS IN 214 PATIENTS

被引:51
作者
CASARA, D
RUBELLO, D
SALADINI, G
GALLO, V
MASAROTTO, G
BUSNARDO, B
机构
[1] UNIV PADUA,DEPT STAT SCI,I-35100 PADUA,ITALY
[2] UNIV PADUA,INST SEMEIOT MED,I-35100 PADUA,ITALY
关键词
D O I
10.1177/030089169107700512
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Long-term results and statistical analysis of prognostic factors in a series of 214 patients with distant metastases from differentiated thyroid cancer (DTC) are reported here. These 214 were part of a total series of 1457 patients with DTC referred to our center from 1967 to 1987. All patients underwent surgery and 131-I therapy and were treated with TSH suppressive doses of thyroid hormones. After a mean follow-up of 7.3 years including clinical, scintigraphic, radiological and laboratory investigations, 24.4% of patients were alive without disease, 36.5% alive with disease, 1.8% dead without disease and 37.3% dead with disease. One of the main factors influencing the survival in our series was 131-I uptake (RIU) by metastatic tissue. No case of complete remission of disease was observed among patients with nonfunctioning metastases. Another important factor was the site of metastases, patients with bone metastases having the worst prognosis. The patient's age at diagnosis represented another important factor for survival; patients over 40 years, particularly those over 60 years had a bad prognosis. A clear interrelation was found among the factors advanced age, nonfunctioning metastases and bone metastases. Patients with these last clinical features were considered to be at high risk and generally had a fatal outcome. Another significant prognostic factor revealed by univariate analysis was the histologic type. Patients with follicular tumor showed a poorer prognosis in comparison to papillary tumor. When multivariate analysis was applied, the factors age at diagnosis, site of metastases and RIU proved to have a significant influence on survival, but not the histologic type. Lastly, the relative rate of males was higher in the group of patients with metastases in comparison to the whole series of DTC patients. Despite this, the factor sex did not influence survival.
引用
收藏
页码:432 / 436
页数:5
相关论文
共 20 条
[1]  
COX DR, 1972, J R STAT SOC B, V34, P187
[2]   COMBINED CHEMOTHERAPY WITH BLEOMYCIN, ADRIAMYCIN, AND PLATINUM IN ADVANCED THYROID-CANCER [J].
DEBESI, P ;
BUSNARDO, B ;
TOSO, S ;
GIRELLI, ME ;
NACAMULLI, D ;
SIMIONI, N ;
CASARA, D ;
ZORAT, P ;
FIORENTINO, MV .
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 1991, 14 (06) :475-480
[3]   CHEMOTHERAPY IN METASTATIC NONANAPLASTIC THYROID-CANCER - EXPERIENCE AT THE INSTITUT-GUSTAVE-ROUSSY [J].
DROZ, JP ;
SCHLUMBERGER, M ;
ROUGIER, P ;
GHOSN, M ;
GARDET, P ;
PARMENTIER, C .
TUMORI, 1990, 76 (05) :480-483
[4]  
HOIE J, 1988, CANCER, V61, P1, DOI 10.1002/1097-0142(19880101)61:1<1::AID-CNCR2820610102>3.0.CO
[5]  
2-R
[6]  
MARCOCCI C, 1989, SURGERY, V106, P960
[7]   PAPILLARY THYROID-CARCINOMA - IMPACT OF THERAPY IN 576 PATIENTS [J].
MAZZAFERRI, EL ;
YOUNG, RL ;
OERTEL, JE ;
KEMMERER, WT ;
PAGE, CP .
MEDICINE, 1977, 56 (03) :171-196
[8]  
MAZZAFERRI EL, 1987, SEMIN ONCOL, V14, P315
[9]  
Pochin E E, 1967, Clin Radiol, V18, P113, DOI 10.1016/S0009-9260(67)80001-1
[10]   USEFULNESS OF THE COMBINED ANTITHYROGLOBULIN ANTIBODIES AND THYROGLOBULIN ASSAY IN THE FOLLOW-UP OF PATIENTS WITH DIFFERENTIATED THYROID-CANCER [J].
RUBELLO, D ;
GIRELLI, ME ;
CASARA, D ;
PICCOLO, M ;
PERIN, A ;
BUSNARDO, B .
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, 1990, 13 (09) :737-742