AN EFFICIENT ENANTIOMERIC 3 STEP SYNTHESIS OF BETA-AMINO ACIDS (ESTERS)

被引：37

作者：

MOKHALLALATI, MK ^{[1
]}

WU, MJ ^{[1
]}

PRIDGEN, LN ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,DEPT SYNTHET CHEM,POB 1539,KING OF PRUSSIA,PA 19406

来源：

TETRAHEDRON LETTERS | 1993年 / 34卷 / 01期

关键词：

D O I：

10.1016/S0040-4039(00)60054-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ethyl tributylstannylacetate was reacted with (R)-2-aryl or alkyl-1,3-oxazolidines 6 under very specific (ZnCl2/Et2O.BF3, 0.5 equiv each) Lewis Acid catalyzed conditions to yield (1R, 1'R)-N-2'-hydroxy-1'-phenylethyl-1-aryl or alkyl-2-carboethoxyethylamine 8 in 91-99% de. The amino alcohol products 8 were converted to aromatic and aliphatic beta-amino esters 9, useful precursors to beta-lactams.

引用

页码：47 / 50

页数：4

共 12 条

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