INCREASED TRKB MESSENGER-RNA EXPRESSION BY AXOTOMIZED MOTONEURONS

被引：64

作者：

PIEHL, F

FRISEN, J

RISLING, M

HOKFELT, T

CULLHEIM, S

机构：

[1] Department of Neuroscience, Karolinska Institute, Stockholm, S-171 77

来源：

NEUROREPORT | 1994年 / 5卷 / 06期

关键词：

REGENERATION; PLASTICITY; NEUROTROPHIN; BDNF; NT-4; SPINAL CORD;

D O I：

10.1097/00001756-199402000-00009

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

IT has been previously demonstrated that members of the neuroptrophin family way prevent death of motoneurones following axotomy. Here we report that the expression of mRNA for full-length trkB, which is a signal transducing receptor for BDNF and NT4, increases transiently in spinal motoneurones after axotomy in adult rats. Thus, transection of the sciatic nerve resulted in markedly increased levels of trkB mRNA in axotomized motoneurones three days postinjury, while the levels had returned to normal within three weeks. The data support that neurotrophins may be important for survival and/or regeneration of motoneurones after axon lesion.

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收藏

页码：697 / 700

页数：4

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