ANALYSIS OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INTEGRASE MUTANTS

被引：59

作者：

ANSARILARI, MA ^{[1
]}

DONEHOWER, LA ^{[1
]}

GIBBS, RA ^{[1
]}

机构：

[1] BAYLOR COLL MED,DIV MOLEC VIROL,HOUSTON,TX 77030

来源：

VIROLOGY | 1995年 / 211卷 / 01期

关键词：

D O I：

10.1006/viro.1995.1412

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The human immunodeficiency virus type-1 (HIV-1) integrase protein (IN) mediates the insertion of linear double-stranded viral DNA into the host genome. Mutations in IN can have different effects on the virus life cycle. In this study, Gag-Pot polyprotein processing, Tat synthesis, and viral replication were investigated in integrase-defective HIV-1 mutants. In the absence of IN synthesis, the Gag-Pol polyprotein stability, packaging, and/or processing was reduced. There was limited expression of Tat observed in IN mutants, but no viral replication. (C) 1995 Academic Press, Inc.

引用

页码：332 / 335

页数：4

共 31 条

[1] Adachi A., Gendelman H.E., Koenig S., Folks T., Willey R., Rabson A., Martin M.A., J. Virol, 59, pp. 284-291, (1986)
[2] Adachi A., Ono N., Sakai H., Shibata R., Kiyomasu T., Masuike H., Ueda S., Arch. Virol, 117, pp. 45-58, (1991)
[3] Ansari-Lari M.A., Gibbs R.A., AIDS Res. Hum. Retroviruses, 10, pp. 1117-1124, (1994)
[4] Bukbnsky M.I., Sharova N., Dempsey M.P., Stanwick T.L., Bukrinskaya A.G., Haggerty S., Stevenson M., Proc. Natl. Acad. Sci. USA, 89, pp. 580-6584, (1992)
[5] Bukrinsky M.I., Sharova N., McDonald T.L., Pushkarskaya T., Tarpley W.G., Stevenson M., Proc. Natl. Acad. Sci. USA, 90, pp. 6125-6129, (1993)
[6] Cannon P.M., Wilson W., Byles E., Ktngsman S.M., Kingsman A.J., J. Virol, 68, pp. 4768-4775, (1994)
[7] Charneau P., Clavel F., J. Virol, 65, pp. 2415-2421, (1991)
[8] Donehower L.A., Varimus H.E., Proc. Natl. Acad. Sci. USA, 81, pp. 6461-6465, (1984)
[9] Donehower L.A., J. Virol, 62, pp. 3958-3964, (1988)
[10] Drelich M., Wilhelm R., Mous J., Virology, 188, pp. 459-468, (1992)

← 1 2 3 4 →