EFFECTS OF ADRENALECTOMY AND TYPE-I OR TYPE-II GLUCOCORTICOID RECEPTOR ACTIVATION ON 5-HT1A AND 5-HT2 RECEPTOR-BINDING AND 5-HT TRANSPORTER MESSENGER-RNA EXPRESSION IN RAT-BRAIN

被引：85

作者：

KURODA, Y

WATANABE, Y

ALBECK, DS

HASTINGS, NB

MCEWEN, BS

机构：

[1] Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10021

来源：

BRAIN RESEARCH | 1994年 / 648卷 / 01期

关键词：

SEROTONIN 5-HT1A RECEPTOR; SEROTONIN; 5-HT2; RECEPTOR; SEROTONIN TRANSPORTER; ADRENALECTOMY; RU28362; ALDOSTERONE;

D O I：

10.1016/0006-8993(94)91916-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We evaluated the effects of adrenalectomy (ADX) and replacement with glucocorticoid receptor agonists on serotonin (5-HT) 5-HT1A and 5-HT2 receptor binding in rat brain. 5-HT1A receptor binding was increased in the CA2-CA4 and the dentate gyrus of the hippocampus 1 week after ADX. This effect was prevented by the systemic administration of aldosterone (10 mu g/mu l/h) but not by RU28362 (10 mu g/mu l/h). No significant effect was observed on 5-HT2 receptor binding in rat cortex. The expression of 5-HT transporter mRNA was unchanged in the raphe nucleus as measured by in situ hybridization.

引用

页码：157 / 161

页数：5

共 16 条

[1]

ALBECK DA, IN PRESS MOL BRAIN R

[2] CORTICOSTERONE MODULATION OF NEUROTRANSMITTER RECEPTORS IN RAT HIPPOCAMPUS - A QUANTITATIVE AUTORADIOGRAPHIC STUDY [J].