AMINODIOL HIV PROTEASE INHIBITORS .2. 1,1-DIMETHYL-2-HYDROXYETHYL CARBAMATE DERIVATIVES WITH ENHANCED POTENCY

被引：12

作者：

BISACCHI, GS

AHMAD, S

ALAM, M

ASHFAQ, A

BARRISH, J

CHENG, PTW

GREYTOK, J

HERMSMEIER, M

LIN, PF

MERCHANT, Z

SKOOG, M

SPERGEL, S

ZAHLER, R

机构：

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1995年 / 5卷 / 05期

关键词：

D O I：

10.1016/0960-894X(95)00056-Y

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of BOG-modified analogs of the aminodiol HIV protease inhibitor EMS-182193 (1) was prepared and tested for inhibitory activity against the enzyme and the virus in cell culture. The hydroxy-modified analogs, 5 and 20, showed enhanced potency against the protease and 5 was more active than 1 against the virus in cell culture.

引用

页码：459 / 464

页数：6

共 7 条

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