4',6'-METHANO CARBOCYCLIC THYMIDINE - A CONFORMATIONALLY CONSTRAINED BUILDING-BLOCK FOR OLIGONUCLEOTIDES

被引：153

作者：

ALTMANN, KH ^{[1
]}

KESSELRING, R ^{[1
]}

FRANCOTTE, E ^{[1
]}

RIHS, G ^{[1
]}

机构：

[1] CIBA GEIGY AG,CENT RES LABS,DEPT PHYS,CH-4002 BASEL,SWITZERLAND

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 15期

关键词：

D O I：

10.1016/0040-4039(94)85212-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of the title compound I has been accomplished in 20 chemical steps starting from D-ribonolactone. X-ray crystallography shows the bicyclic skeleton of 1 to adopt a boat-like (''2'-exo'') conformation and preliminary hybridization data indicate that the substitution of 1 for natural thymidine in DNA/RNA heteroduplexes may increase their thermodynamic stability.

引用

页码：2331 / 2334

页数：4

共 26 条

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