DIACYLGLYCEROL KINASE - A KEY MODULATOR OF SIGNAL TRANSDUCTION

被引：193

作者：

KANOH, H

YAMADA, K

SAKANE, F

机构：

[1] Department of Biochemistry, Sapporo Medical College West-17, Sapporo, 060

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1990年 / 15卷 / 02期

关键词：

D O I：

10.1016/0968-0004(90)90172-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Diacylglycerol kinase (DGK) plays a central role in the metabolism of diacylglycerol released as a second messenger in agonist-stimulated cells. The major purified form of the enzyme (80 kDa DGK) is highly abundant in lymphocyte cytosol and may become membrane-associated via phosphorylation by protein kinase C. In addition, there are several kinase subspecies immunologically distinct from the 80 kDa enzyme, which differ markedly in their responses to several compounds such as sphingosine and R59022. Thus, further work on each enzyme species is needed to define the function of DGK in stimulated cells. © 1990.

引用

页码：47 / 50

页数：4

共 41 条

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