TYPING OF SOUTHERN AFRICAN ISOLATES OF PLASMODIUM-FALCIPARUM USING MONOCLONAL-ANTIBODIES

被引：3

作者：

FREESE, JA

MARKUS, MB

GOLENSER, J

机构：

[1] UNIV WITWATERSRAND,DEPT ZOOL,JOHANNESBURG 2001,SOUTH AFRICA

[2] HEBREW UNIV JERUSALEM,HADASSAH MED SCH,KUVIN CTR TROP DIS,IL-91010 JERUSALEM,ISRAEL

来源：

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE | 1990年 / 43卷 / 01期

关键词：

D O I：

10.4269/ajtmh.1990.43.19

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Antigenic diversity among 19 southern African isolates of Plasmodium falciparum was demonstrated using a panel of 9 monoclonal antibodies. Parasites obtained from single patients were heterogeneous. The antigen composition of 9 isolates was not stable with time in culture, particularly not with respect to 4 of the monoclonal antibodies. By the end of the investigation, 70% of isolates displayed an identical antigen pattern which was markedly different to any obtained in other parts of the world. Differences may be due to geographic origin of parasites or to variation in culture conditions.

引用

收藏

页码：19 / 24

页数：6

相关论文

共 15 条

[1] DETECTION OF PLASMODIUM-FALCIPARUM USING A RADIOIMMUNOASSAY BASED ON A CROSSREACTING, MONOCLONAL ANTI-PLASMODIUM-BERGHEI ANTIBODY-PLASMODIUM-BERGHEI ANTIGEN SYSTEM [J].

AVIDOR, B ;

GOLENSER, J ;

SULITZEANU, D .

JOURNAL OF IMMUNOLOGICAL METHODS, 1985, 82 (01) :121-129

[2] CHARACTERIZATION OF PLASMODIUM-FALCIPARUM ISOLATES FROM RONDONIA STATE, BRAZIL, BY DRUG SUSCEPTIBILITY, ENZYME TYPING AND MONOCLONAL-ANTIBODIES [J].

DISANTI, SM ;

BOULOS, M ;

VASCONCELOS, MA ;

OLIVEIRA, S ;

COUTO, A ;

ROSARIO, VE .

REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO, 1987, 29 (03) :142-147

[3] POLYMORPHISM OF A 35-48 KDA PLASMODIUM-FALCIPARUM MEROZOITE SURFACE-ANTIGEN [J].

FENTON, B ;

CLARK, JT ;

WILSON, CF ;

MCBRIDE, JS ;

WALLIKER, D .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1989, 34 (01) :79-86

[4]

FREESE JA, 1988, S AFR MED J, V73, P720

[5] PLASMODIUM-FALCIPARUM IN CULTURE - ESTABLISHMENT OF ADDITIONAL STRAINS [J].

JENSEN, JB ;

TRAGER, W .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1978, 27 (04) :743-746

[6] ANTIGENIC DIVERSITY FOUND IN ISOLATES OF PLASMODIUM-FALCIPARUM FROM PAPUA NEW GUINEA BY USING MONOCLONAL-ANTIBODIES [J].

KNOWLES, G ;

DAVIDSON, WL ;

MCBRIDE, JS ;

JOLLEY, D .

AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 1984, 33 (02) :204-211

[7] POLYMORPHISM OF A HIGH MOLECULAR-WEIGHT SCHIZONT ANTIGEN OF THE HUMAN MALARIA PARASITE PLASMODIUM-FALCIPARUM [J].

MCBRIDE, JS ;

NEWBOLD, CI ;

ANAND, R .

JOURNAL OF EXPERIMENTAL MEDICINE, 1985, 161 (01) :160-180

[8] SEROTYPING PLASMODIUM-FALCIPARUM FROM ACUTE HUMAN INFECTIONS USING MONOCLONAL-ANTIBODIES [J].

MCBRIDE, JS ;

WELSBY, PD ;

WALLIKER, D .

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 1984, 78 (01) :32-34

[9] ANTIGENIC DIVERSITY IN THE HUMAN MALARIA PARASITE PLASMODIUM-FALCIPARUM [J].

MCBRIDE, JS ;

WALLIKER, D ;

MORGAN, G .

SCIENCE, 1982, 217 (4556) :254-257

[10] USE OF A MONOCLONAL, ANTI PLASMODIUM-BERGHEI ANTIBODY, CROSS REACTING WITH P-FALCIPARUM, FOR THE DETECTION OF P-FALCIPARUM IN INVITRO INFECTED BLOOD [J].

PASS, A ;

AVIDOR, B ;

GOLENSER, J ;

LASKOV, R ;

SULITZEANU, D .

IMMUNOLOGY LETTERS, 1985, 10 (01) :31-34