ROLE OF PORES IN DISSOLUTION PROCESSES

被引：8

作者：

VANDERGRAAFF, H ^{[1
]}

DEBOER, BB ^{[1
]}

DEBLAEY, CJ ^{[1
]}

机构：

[1] STATE UNIV LEIDEN,GORLAEUS LABS,SUBFAC PHARM,DEPT PHARMACEUT,LEIDEN,NETHERLANDS

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1979年 / 3卷 / 06期

关键词：

D O I：

10.1016/0378-5173(79)90121-2

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

The influence of pores on the dissolution rate of non-disintegating sodium chloride tablets was investigated. Artificial pores of different diameters were created by drilling in highly compressed tablets. The dissolution rate increase appearen to be dependent on the pore diameter, and was supposed to be caused by an enlarged dissolution surface. By comparison of the - geometry based - predicted dissolution rate increase and the experimental results, the contribution of the pores to the dissolution under experimental conditions could be calculated. The diameter below which the inside of the pores take no part in dissolution, has been estimated by extrapolation at approximately 200 μm. © 1979.

引用

页码：293 / 297

页数：5

共 6 条

[1]

Armand H, 1975, J Pharm Belg, V30, P159

[2]

DISSOLUTION KINETICS OF SOLUBLE NON-DISINTEGRATING DISKS [J].

BLAEY, CJD ;

VANDERGRAAFF, H .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1977, 66 (12) :1696-1699

[3]

LEVICH VG, 1962, PHYSICOCHEMICAL HYDR

[4]

INVESTIGATION OF DRUG RELEASE FROM SOLIDS .1. SOME FACTORS INFLUENCING THE DISSOLUTION RATE [J].

PARROTT, EL ;

WURSTER, DE ;

HIGUCHI, T .

JOURNAL OF THE AMERICAN PHARMACEUTICAL ASSOCIATION, 1955, 44 (05) :269-273

[5]

Wagner JG, 1971, BIOPHARMACEUTICS REL

[6]

INVESTIGATION OF DRUG RELEASE FROM SOLIDS .3. EFFECT OF A CHANGING SURFACE-WEIGHT RATIO ON THE DISSOLUTION RATE [J].

WURSTER, DE ;

SEITZ, JA .

JOURNAL OF THE AMERICAN PHARMACEUTICAL ASSOCIATION, 1960, 49 (06) :335-338

← 1 →