A MULTISTAGE MODEL OF CARCINOGENESIS INCORPORATING DNA DAMAGE AND REPAIR

被引：34

作者：

PORTIER, CJ ^{[1
]}

KOPPSCHNEIDER, A ^{[1
]}

机构：

[1] DEUTSCH KREBSFORSCHUNGSZENTRUM,INST EPIDEMIOL & BIOMETRIE,BIOSTAT ABT,W-6900 HEIDELBERG,GERMANY

来源：

RISK ANALYSIS | 1991年 / 11卷 / 03期

关键词：

2-STAGE MODEL; STOCHASTIC MODEL; BIRTH-DEATH PROCESS; RISK ASSESSMENT;

D O I：

10.1111/j.1539-6924.1991.tb00639.x

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Mathematical models of carcinogenesis are one tool used for research into the mechanisms of carcinogenesis and for assessing risks from exposure to carcinogenic agents. Recent research into carcinogenic mechanisms has focused on the role of cell replication in fixing damage to cellular DNA and increasing the incidence of malignancies. The most commonly used multistage model of carcinogenesis does not explicitly account for DNA damage and the contribution of cell replication rates on the transformation of cells through the various stages. In this manuscript, a generalized multistage model of carcinogenesis is developed in which DNA damage, cell replication, and DNA repair are explicitly included. Copyright © 1991, Wiley Blackwell. All rights reserved

引用

页码：535 / 543

页数：9

共 31 条

[1] PHYSIOLOGICALLY BASED PHARMACOKINETICS AND THE RISK ASSESSMENT PROCESS FOR METHYLENE-CHLORIDE [J].

ANDERSEN, ME ;

CLEWELL, HJ ;

GARGAS, ML ;

SMITH, FA ;

REITZ, RH .

TOXICOLOGY AND APPLIED PHARMACOLOGY, 1987, 87 (02) :185-205

[2] ISSUES IN BIOCHEMICAL APPLICATIONS TO RISK ASSESSMENT - HOW DO WE EVALUATE INDIVIDUAL COMPONENTS OF MULTISTAGE MODELS [J].

ANDERSON, MW .

ENVIRONMENTAL HEALTH PERSPECTIVES, 1987, 76 :175-179

[3] THE AGE DISTRIBUTION OF CANCER AND A MULTI-STAGE THEORY OF CARCINOGENESIS [J].

ARMITAGE, P ;

DOLL, R .

BRITISH JOURNAL OF CANCER, 1954, 8 (01) :1-12

[4] THE ROLE OF CROTON OIL APPLICATIONS, ASSOCIATED WITH A SINGLE PAINTING OF A CARCINOGEN, IN TUMOUR INDUCTION OF THE MOUSES SKIN [J].

BERENBLUM, I ;

SHUBIK, P .

BRITISH JOURNAL OF CANCER, 1947, 1 (04) :379-382

[5]

BIGGER CAH, 1983, CANCER RES, V43, P5647

[6] CELL-PROLIFERATION KINETICS AND MULTISTAGE CANCER RISK MODELS [J].

BOGEN, KT .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1989, 81 (04) :267-277

[7]

DAY NE, 1980, JNCI-J NATL CANCER I, V64, P977

[8]

FARBER E, 1984, CANCER RES, V44, P5463

[9]

FRIEBERG EC, 1988, UCLA S MOL CELLULAR, V83

[10]

GOLDSTEIN S, 1989, 50 U WISC MAD BIOST

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