STRUCTURAL MODIFICATIONS ASSOCIATED WITH THE CHANGE IN CA2+ SENSITIVITY ON ACTIVATION OF M-CALPAIN

被引：66

作者：

BROWN, N ^{[1
]}

CRAWFORD, C ^{[1
]}

机构：

[1] UNIV OXFORD,MOLEC BIOPHYS LAB,REX RICHARDS BLDG,S PARKS RD,OXFORD OX1 3QU,ENGLAND

来源：

FEBS LETTERS | 1993年 / 322卷 / 01期

基金：

英国医学研究理事会;

关键词：

CA2+-DEPENDENT PROTEASE; CA2+ SENSITIVITY; CALPAIN ACTIVATION; AUTOLYSIS;

D O I：

10.1016/0014-5793(93)81112-D

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Autolysis of the Ca2+-dependent cysteine protease m-calpain involves cleavage of the large (80 kDa) and small (30 kDa) subunits of the enzyme, and an increase in Ca2+ sensitivity. The appearance of increased Ca2+ sensitivity was found to correlate with the cleavage of the large subunit after residue 9.

引用

页码：65 / 68

页数：4

共 21 条

[1] COMPLETE AMINO-ACID-SEQUENCE OF THE LARGE SUBUNIT OF THE LOW-CA-2+-REQUIRING FORM OF HUMAN CA-2+-ACTIVATED NEUTRAL PROTEASE (MU-CANP) DEDUCED FROM ITS CDNA SEQUENCE
AOKI, K
IMAJOH, S
OHNO, S
EMORI, Y
KOIKE, M
KOSAKI, G
SUZUKI, K
[J]. FEBS LETTERS, 1986, 205 (02) : 313 - 317
[2] COOLICAN SA, 1984, J BIOL CHEM, V259, P1627
[3] CORALL DE, 1992, BIOCHIM BIOPHYS ACTA, V1121, P47
[4] THE EFFECTS OF AUTOLYSIS ON THE STRUCTURE OF CHICKEN CALPAIN-II
CRAWFORD, C
WILLIS, AC
GAGNON, J
[J]. BIOCHEMICAL JOURNAL, 1987, 248 (02) : 579 - 588
[5] INVESTIGATION OF THE STRUCTURAL BASIS OF THE INTERACTION OF CALPAIN-II WITH PHOSPHOLIPID AND WITH CARBOHYDRATE
CRAWFORD, C
BROWN, NR
WILLIS, AC
[J]. BIOCHEMICAL JOURNAL, 1990, 265 (02) : 575 - 579
[6] CALCIUM-ACTIVATED NEUTRAL PROTEASE (CALPAIN) SYSTEM - STRUCTURE, FUNCTION, AND REGULATION
CROALL, DE
DEMARTINO, GN
[J]. PHYSIOLOGICAL REVIEWS, 1991, 71 (03) : 813 - 847
[7] COMPARISON OF LOW-CALCIUM AND HIGH-CALCIUM-REQUIRING FORMS OF THE CALCIUM-ACTIVATED PROTEASE WITH THEIR AUTOCATALYTIC BREAKDOWN PRODUCTS
DAYTON, WR
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1982, 709 (02) : 166 - 172
[8] DEMARTINO GN, 1986, J BIOL CHEM, V261, P2047
[9] HATHAWAY DR, 1982, J BIOL CHEM, V257, P9072
[10] MOLECULAR-CLONING OF THE CDNA FOR THE LARGE SUBUNIT OF THE HIGH-CA-2+-REQUIRING FORM OF HUMAN CA-2+-ACTIVATED NEUTRAL PROTEASE
IMAJOH, S
AOKI, K
OHNO, S
EMORI, Y
KAWASAKI, H
SUGIHARA, H
SUZUKI, K
[J]. BIOCHEMISTRY, 1988, 27 (21) : 8122 - 8128

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