BIOCHEMICAL AND FLUORODOPA POSITRON EMISSION TOMOGRAPHIC FINDINGS IN AN ASYMPTOMATIC CARRIER OF THE GENE FOR DOPA-RESPONSIVE DYSTONIA

被引：43

作者：

TAKAHASHI, H

LEVINE, RA

GALLOWAY, MP

SNOW, BJ

CALNE, DB

NYGAARD, TG

机构：

[1] COLUMBIA UNIV,COLUMBIA PRESBYTERIAN MED CTR,DEPT NEUROL,NEW YORK,NY 10032

[2] UNIV BRITISH COLUMBIA,CTR NEURODEGENERAT DISORDER,DIV NEUROL,VANCOUVER,BC,CANADA

[3] WAYNE STATE UNIV,SCH MED,DEPT PSYCHIAT,DETROIT,MI

来源：

ANNALS OF NEUROLOGY | 1994年 / 35卷 / 03期

关键词：

D O I：

10.1002/ana.410350317

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We report cerebrospinal fluid monoamine metabolite analyses and 6‐[18F]fluoro‐1‐dopa positron emission tomography (FD‐PET) from an asymptomatic carrier of the gene for dopa‐responsive dystonia. Cerebrospinal fluid homovanillic acid, tetrahydrobiopterin, and neuropeterin concentrations were reduced in this man and in his affected children. His FD‐PET was normal, as we have previously found in dopa‐responsive dystonia. Neurological function and FD‐PET may be normal despite marked abnormality in dopamine metabolism. Copyright © 1994 American Neurological Association

引用

页码：354 / 356

页数：3

共 17 条

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