OLIGONUCLEOTIDES IN THE TREATMENT OF LEUKEMIA

被引：19

作者：

BAYEVER, E ^{[1
]}

IVERSEN, P ^{[1
]}

机构：

[1] UNIV NEBRASKA,MED CTR,DEPT PHARMACOL,OMAHA,NE 68198

来源：

HEMATOLOGICAL ONCOLOGY | 1994年 / 12卷 / 01期

关键词：

ANTISENSE OLIGONUCLEOTIDES; HUMAN LEUKEMIA;

D O I：

10.1002/hon.2900120103

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The use of synthetic oligonucleotides directed towards specific genes in the therapy of leukemias has evolved rapidly over the past 5 years to early clinical trials. Undoubtedly, use of these compounds for systemic therapy and bone marrow 'purging' will escalate. Such trials will be models for the treatment of many other malignant diseases and, indeed, non-malignant diseases which may be expected to respond to eradication of a specific gene function. We are currently at the threshold of a new era of therapy which holds the promise of totally transforming clinical medicine in the next decade.

引用

页码：9 / 14

页数：6

共 35 条

[1] PHARMACOKINETICS, BIODISTRIBUTION, AND STABILITY OF OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATES IN MICE [J].