THE GLYCOPROTEIN-B HOMOLOG OF HUMAN HERPESVIRUS-6

被引:34
作者
ELLINGER, K
NEIPEL, F
FOATOMASI, L
CAMPADELLIFIUME, G
FLECKENSTEIN, B
机构
[1] UNIV ERLANGEN NURNBERG, INST KLIN & MOLEK VIROL, LOSCHGESTR 7, W-8520 ERLANGEN, GERMANY
[2] UNIV BOLOGNA, SEZ MICROBIOL & VIROL, I-40126 BOLOGNA, ITALY
关键词
D O I
10.1099/0022-1317-74-3-495
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
The gene for the homologue of herpesvirus glycoprotein B (gB) has been identified in the genome of human herpesvirus 6 (HHV-6), strain U 1 102, and the nucleotide sequence was determined. The open reading frame encodes a protein of 830 amino acids (93.2K) with the characteristics of a transmembrane glycoprotein and close similarity to the gp58/116 complex of human cytomegalovirus (HCMV). Monoclonal antibodies 2D10 and 2B9 have been shown previously to react with an HHV-6 glycoprotein of apparent M(r) 112K, and its proteolytic cleavage products of M(r) 64K and 58K. We show that both monoclonal antibodies detect prokaryotically expressed carboxy-terminal fragments of the HHV-6 gB homologue. This indicates that the HHV-6 gB homologue is probably processed by proteolytic cleavage similar to its equivalents in HCMV and various other herpesviruses.
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页码:495 / 500
页数:6
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