SYNTHESIS AND IN-VITRO CYTOTOXICITY OF DIASTEREOISOMERICALLY MODIFIED DOLASTATIN-15 ANALOGS

被引：8

作者：

ROUX, F

GALEOTTI, N

PONCET, J

JOUIN, P

CROS, S

ZENKE, G

机构：

[1] LAB MECANISMES MOLEC COMMUN CELLULAIRES,F-34094 MONTPELLIER 5,FRANCE

[2] CNRS,PHARMACOL & TOXICOL FONDAMENTALES LAB,F-31077 TOULOUSE,FRANCE

[3] SANDOZ PHARMA LTD,CH-4002 BASEL,SWITZERLAND

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 16期

关键词：

DOLASTATIN; DEPSIPEPTIDE; CYTOSTATIC ACTIVITY; ANTIPROLIFERATIVE EFFECT;

D O I：

10.1016/S0960-894X(01)80540-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Dolastatin 15 1(4S,7S) is a potent cytostatic depsipeptide of marine origin. Analysis of the effects of the stereochemistry in the non-peptide moiety on activity revealed that chirality inversion in the aromatic terminal region preserves the antiproliferative activity.

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页码：1947 / 1950

页数：4

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