AGING, LATE-ONSET ASTHMA AND THE BETA-ADRENOCEPTOR

Late-onset asthma in old age is a common clinical problem. There are similarities between receptor and post-receptor beta(2)-adrenoceptor abnormalities reported in young asthmatics and in elderly normal subjects. Recent evidence lends some support to the idea of the 'ageing' beta(2)-adrenoceptor as a contributory factor in the development of late-onset asthma, although questions of the validity of the peripheral mononuclear cell model and of receptor tachyphylaxis to intrinsic and extrinsic beta-adrenoceptor agonists remain unresolved. Further work should focus on in vivo studies of airway receptor function and on beta(2)-adrenoceptor-mediated pathways other than smooth muscle-related bronchoconstriction.