INTRAMOLECULAR SIGNAL-TRANSDUCTION IN C-JUN

被引：114

作者：

PAPAVASSILIOU, AG ^{[1
]}

TREIER, M ^{[1
]}

BOHMANN, D ^{[1
]}

机构：

[1] EUROPEAN MOLEC BIOL LAB,DIFFERENTIAT PROGRAM,D-69012 HEIDELBERG,GERMANY

来源：

EMBO JOURNAL | 1995年 / 14卷 / 09期

关键词：

C-JUN; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTOR AP-1;

D O I：

10.1002/j.1460-2075.1995.tb07193.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The DNA-binding activity of c-Jun is determined by the phosphorylation state of a cluster of threonine and serine residues located near its COOH-terminus. We have analyzed the events that lead to c-Jun activation via dephosphorylation of these sites in response to phorbol esters. Our results indicate that COOH-terminal dephosphorylation is an indirect consequence of a separate phosphorylation event targeted to the NH2-terminus of c-Jun. Thus, the activation of c-Jun DNA-binding potential, caused by COOH-terminal dephosphorylation, may not require the regulation of the kinase/phosphatase system that brings about this change, but rather an alteration in the accessibility of the COOH-terminal phosphoacceptor sites of c-Jun.

引用

页码：2014 / 2019

页数：6

共 23 条

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