INFLUENCE OF AGING AND SEX ON SPECIFIC IGE ANTIBODY-PRODUCTION

被引：15

作者：

NAKAZAWA, T

HOUJYO, S

DOBASHI, K

SATO, K

机构：

[1] College of Medical Care and Technology, Gunma University, Maebashi, Gunma, 371

[2] Department of Internal Medicine, Gunma University, Maebashi

来源：

INTERNAL MEDICINE | 1994年 / 33卷 / 07期

关键词：

MITES; JAPANESE CEDAR POLLEN (JCP); FLUORESCENCE ENZYME IMMUNOASSAY (FEIA); RELATIVE FLUORESCENCE UNITS (RFU);

D O I：

10.2169/internalmedicine.33.396

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The influence of aging and sex on specific IgE production was evaluated in a non-allergic population aged from 18 to 99 years. Specific IgE against mite antigen and Japanese cedar pollen (JCP) were measured by fluorescence enzyme immunoassay. The incidence and titer of positive anti-mite and anti-JCP IgE antibodies decreased with age, particularly in the aged group. There were slight sex-related changes in IgE production. No significant correlation was noted between anti-mite and anti-JCP IgE antibody levels in the same individual subjects. These findings suggest that the production of specific IgE, as an immunoglobulin class, declines with aging.

引用

页码：396 / 401

页数：6

共 18 条

[1]

Stoy P.J., Roitman-Johnson B., Walsh G., Gleich G.J., Et al., Aging and serum immunoglobulin E level, immediate skin tests and RAST, J Allergy Clin Immunol, 68, (1981)

[2]

Barbee R.A., Brown W.G., Kaltenbom W., Halonen M., Allergen skin test reactivity in a community population sample. Correlation with age, histamine skin reactions and serum IgE, J Allergy Clin Immunol, 68, (1981)

[3]

Hanneuse Y., Delespesse G., Hudson D., DeHalleux F., Jacques J.M., Influence of aging on IgE-mediated reactions in allergic patients, Clin Allergy, 8, (1978)

[4]

Sato K., Nakazawa T., Age-related changes in specific IgE antibody production, Ann Allergy, 68, (1992)

[5]

Nakazawa T., Sato K., Tsuchiya J., Evaluation of release fluoroimmuno-assay for the determination of specific IgE antibody to Japanese cedar pollinosis, Clin Allergy, 61, (1988)

[6]

Ishizaki T., Koizumi K., Ikemori R., Ishiyama Y., Kushibiki E., Studies of prevalence of Japanese cedar pollinosis among residents in a density cultivated area, Ann Allergy, 58, (1987)

[7]

Barbee R.A., Lebowitz M.D., Thomson H.C., Burrows B., Immediate skin test reactivity in a general population sample, Ann Intern Med, 84, (1976)

[8]

Orren A., Dowdle E.B., The effect of sex and age on serum IgE concentrations in three ethnic groups, Int Archs Allergy Appl Immunol, 48, (1975)

[9]

Enomoto M., Iwahashi D., Nakanishi H., Relationship between aging and total IgE, IgE RAST score, specific IgG content in sera, Kiso to Rinsho, 20, (1986)

[10]

Meretey K., Jakab A., Szilassy K., IgE levels in normal human sera and IgE preparation, Haematologia, 22, (1989)

← 1 2 →