INTERRUPTION OF ATRIAL FIBRILLATION BY PACEMAKER SHIFT INDUCED BY SELECTIVE USE OF NORADRENALINE INTO A-V NODE ARTERY - PRELIMINARY REPORT

The selective administration of noradrenaline into the A-V node artery (posterior septal artery) induced the shift of pacemaker from the sinus rhythm to A-V nodal tachycardia following gradual shortening of PQ interval. When the A-V nodal rhythm was established, the selective administration of acetylcholine into the sinus node artery could not induce atrial fibrillation which was, however, regularly induced by the same procedure in the normal sinus rhythm. Further more, sustained atrial fibrillation induced by continuous administration of acetyl choline or carbachol into the sinus node artery was blocked by the administration of noradrenaline into the A-V node artery, while the pacemaker was shifted to the A-V node. It is suggested that the atrial fibrillation occurs when the sinoatrial node keeps its dominance over the subsidiary pacemaker of A-V node. © 1968, Tohoku University Medical Press. All rights reserved.