[3-(2-MERCAPTOETHYLAMINO)PROPYL]OXAMIDE AND RELATED COMPOUNDS AS POTENTIAL ANTIRADIATION AGENTS

被引：7

作者：

ELLIOTT, RD

JOHNSTON, TP

机构：

[1] Kettering-Meyer Laboratory, Southern Research Institute, Birmingham

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1969年 / 12卷 / 03期

关键词：

D O I：

10.1021/jm00303a607

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Thiols and the corresponding hydrogen thiosulfate esters were prepared as potential radioprotective agents from [ω-(1-aziridinyl)alkyl]oxamides by ring-opening reactions. Of 18 such compounds prepared, only [3-(2-mercaptoethylamino)propyl]oxamide (6a) showed considerable radioprotective activity in mice. © 1969, American Chemical Society. All rights reserved.

引用

页码：507 / &

共 14 条

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[10] S-2-(OMEGA-AMINOALKYLAMINO)ETHYL DIHYDROGEN PHOSPHOROTHIOATES AND RELATED COMPOUNDS AS POTENTIAL ANTIRADIATION AGENTS
PIPER, JR
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ELLIOTT, RD
JOHNSTON, TP
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1969, 12 (02) : 236 - +

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