INTRACELLULAR BINDING OF CORTICOSTERONE IN THYMUS TISSUE

被引：18

作者：

BRUNKHORST, WK

机构：

[1] Worcester Foundation for Experimental Biology Shrewsbury

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1969年 / 35卷 / 06期

基金：

俄罗斯科学基金会;

关键词：

D O I：

10.1016/0006-291X(69)90706-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The intracellular distribution of radioactivity was determined in rat thymus cells 15, 45 and 90 minutes after the animals had received intraperitoneal injections of corticosterone-1,2-H3. Cytoplasmic and nuclear fractions were isolated and the nuclei were fractionated to yield various components of the chromatin structure. Radioactivity of cytoplasmic fractions decreased rapidly from an initial high level at 15 minutes. The concentration of radioactivity associated with histones and with material solubilized by DNAse increased during the time interval studied. This observation suggests a possible specific receptor site for glucocorticoids in thymocyte nuclei. © 1969.

引用

页码：880 / +

页数：1

共 9 条

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